I would also send out a pdf master copy periodically, so they couldn’t edit that one by mistake. I would give anyone contributing a master copy of the RFP request, and a formatted copy of the material relevant to them. It is also easier if you plan on sending out portions of the document for different people.Īnother good example of this trick is when I was running Requests For Proposals (RPFs) as a Systems Engineer. Breaking things into smaller documents will make things load faster, scroll better, and all around make your life happier during your Word work. If not, break them into smaller logical segments.įor example, when I was writing my VCDX document, I had one document for the Conceptual Model, another for Logical/Physical Network Design, Logical/Physical Compute design, etc. If you are writing a book, break down your Microsoft Word documents into chapters. Break your large document into more manageable word documents. Managing everything in one huge, long Word document is just a terrible idea. After you have the content in your document, then use a style to format it properly.īreak Down Your Large Microsoft Word Document If you are doing a lot of copying, make sure you are pasting as either unformatted text, or using the tool which will remove formatting after pasting circled below. Whenever you write some sort of text, use a style! Create styles for bullets, tables, lists, you name it! If it is in your document, it should have a style! Creating a new style is as easy as clicking New Style, giving it a name, and setting its attributes. Make sure to give them a descriptive name, so you know what each style is for as you write.Ĭlick home, then Styles Pane on the right to see the Styles in your document. If you aren’t using a template, styles are super easy to create and customize. Take a few minutes to review them, and get an understanding of what they are used for. If you are using a template, hopefully you have some styles set up for you already in it. The second important aspect to starting strong is taking advantage of Styles in Microsoft Word. This way, I can see how my outline has progressed. I usually brainstorm with a paper outline, then write my working outline in Microsoft Word, and turn on Track Changes. This means a couple of things.įirst, write yourself an outline, in whatever medium you like. If you know you’re going to be working on a huge long document, make sure you get off to a strong start. Start Strong With Planning Your Large Document Let’s talk about some strategies to approaching large word documents. The worst thing you could do in any of these cases is write everything down in a single long Word document. If you are a student, writer, or professional, you will eventually encounter a large Microsoft Word document. I am here to give you some tips and tricks I have picked up along the way dealing with long documents, specifically using Microsoft Word. Large word documents, are nothing to fear, I promise. You may end up with a monster document, whether it be for work report, writing a novel for fun, or writing your VCDX design. If you have not had the pleasure of managing a document hundreds of pages long, I am quite happy for you! However, this does not mean you will not have to at some point.
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD024149.įunding: This study was supported by a Boston University CTSI Award as part of National Institutes of Health #UL1TR0014300 (UH and AE), a Boston University OTD Ignition Award (UH), and National Institutes of Health #R01GM078240 (SES). Received: JanuAccepted: Published: June 15, 2022Ĭopyright: © 2022 Yunes et al. PLoS ONE 17(6):Įditor: Claude Prigent, Centre de Recherche en Biologie cellulaire de Montpellier, FRANCE (2022) Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins. Probing the mitotic LSF interactome using small molecule inhibitors therefore supported a non-transcriptional role for LSF in mediating progression through mitosis.Ĭitation: Yunes SA, Willoughby JLS, Kwan JH, Biagi JM, Pokharel N, Chin HG, et al. In particular, and consistent with spindle disruption due to FQI treatment, mitotic, FQI1-sensitive interactions were identified between the biotinylated LSF and microtubule-associated proteins that regulate spindle assembly, positioning, and dynamics, as well as centrosome-associated proteins. The global proteomics analysis yielded expected associations for a transcription factor, notably with RNA processing machinery, but also to nontranscriptional components. To probe whether the FQI1-mediated spindle abnormalities could result from inhibition of mitotic LSF-protein interactions, mass spectrometry was performed using as bait an inducible, tagged form of LSF that is biotinylated by endogenous enzymes. Consistent with a microtubule role for LSF, here we show that LSF enhanced the rate of tubulin polymerization in vitro, and FQI1 inhibited such polymerization. Other transcription factors participate in mitosis through non-transcriptional means, and we recently reported that LSF directly binds α-tubulin and is present in purified cellular tubulin preparations. Previously, FQIs were shown to specifically inhibit not only LSF DNA-binding activity, which requires LSF oligomerization to tetramers, but also other specific LSF-protein interactions. These phenotypes suggest that perturbation of spindle microtubules is the primary event leading to the mitotic delays upon FQI1 treatment. Aberrant γ-tubulin localization was also observed. Furthermore, treatment with FQIs resulted in a striking, concentration-dependent diminishment of spindle microtubules, accompanied by a concentration-dependent increase in multi-aster formation. Here, we show that FQI1 can rapidly and reversibly lead to mitotic arrest, even when added directly to mitotic cells, implying that FQI1-mediated mitotic defects are not transcriptionally based. FQI1, the initial lead compound identified, unexpectedly induced a concentration-dependent delay in mitotic progression. Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. Others cannot be relied upon to determine what will be meaningful to us. – The question of what makes life meaningful has to be answered personally (even if our conclusions are marked by no particular idiosyncrasy). They are those we most highly value and will, from the perspective of our deaths, regret most deeply. – Meaningful activities aren’t necessarily those we do most often. Meaningful activities leave something behind, even when the emotions that once propelled us into them have passed. Projects, relationships, interests and commitments will build up cumulatively. – A meaningful life is bound up with the long-term. We may be leading a meaningful life and yet, really rather often, be in a bad mood (just as we may be having frequent surface fun while living, for the most part, meaninglessly). – A meaningful life aims not so much at day-to-day contentment as fulfilment. – A meaningful life draws upon, and exercises, a range of our higher capacities, for example, those bound up with tenderness, care, connection, self-understanding, sympathy, intelligence and creativity. This is a guidebook to it.Ī meaningful life is close to, but at points importantly different from, a happy life. A meaningful life can be simple in structure, personal, usable, attractive and familiar. There need be nothing forbidding about the issue. Yet, in truth, the subject is for everyone it is for all of us to wonder about, and define, a meaningful existence. Without always acknowledging it, we are – in the background – operating with a remarkably ungenerous perspective on the meaning of life. It wouldn’t be anything that could orient or illuminate our activities. If ever we did discover the meaning, it would – we suspect – in any case be incomprehensible, perhaps written in Latin or in computer code. Meaningful lives are for extraordinary people: great saints, artists, scholars, scientists, doctors, activists, explorers, national leaders…. A select few might be equipped to take on the task and discover the answer in their own lives, but such ambition isn’t for most of us. It isn’t anything an ordinary mortal should be doing – or would get very far by doing. 'Screaming Out', the juggernaut heavy title track (very debut album from CG), 'The Dark', 'Silent Messiah'.all razor sharp and deadly.To wonder too openly, or intensely, about the meaning of life sounds like a peculiar, ill-fated and unintentionally comedic pastime. two songs in and I'm already sold! And it just gets better and better. The customary slow burning intro of opener 'Irresistible' eventually gives way to one of the best early Savatage riffs I've heard in years and comes complete with sky skimming vocals a la Halford circa the aforementioned 'Painkiller'.spookily, the second time that comparison has struck me right between the eyes in as many days (see Primal Fear review HERE).Īnd just as you've picked your jaw up from off the floor, along comes 'March Of Madness' with its unmistakably classic Queensrÿche vibe. Most of the tracks are in that punchy four to five minute bracket, yet despite the dominance of those thunderous drum/bass runs and a profusion of searing riffs, the melodies are just as strong as (if not stronger than) ever. I have to congratulate vocalist Samuel Nyman because last time round I thought he was the weakest link in the band, but on the evidence before me here, he seems to have come on in leaps and bounds – very Rob Halford meets Midnite! Impressing straight out of the box with their mix of Progressive moods and sounds a la Queensrÿche and Nocturnal Rites, the aforementioned debut was certainly one of the better releases of that year, and when similar lists for 2015 come to be compiled shortly, I'm fairly confident that 'Trapped In The Shadows' will once again feature prominently.Ī little straighter than its predecessor (although there's still a modicum of Progressive flair on display), this latest release sees Manimal opt for a riff heavy attack that reminds me of 'Painkiller' era Judas Priest mixed in with Queensrÿche and Crimson Glory. I was quite impressed with the debut but this one just blows that out of the water!įormed as long ago as 2001, it took Gothenburg-based quartet Manimal the best part of a decade to issue their debut album – 2009's 'The Darkest Room' – so I suppose it shouldn't really come as a surprise that sophomore album 'Trapped In The Shadows' took almost as long.īack in the good old days (unless you were Boston or Def Leppard of course) such a protracted gap between releases would almost certainly have led to the band's demise fortunately, such rules seem to have been thrown out of the window in this post download age.
Cover letter templates for resumes: your resume or curriculum vitae, or download the CV cover letter in PDF separately. Students, first-time job seekers (Freshers) or entry-level positions, engineering college student internships, off-campus interviews, and experienced job hunters will benefit from the sections.ģ. Resume helper: Samples and examples of resumes for each position. To create a curriculum vitae, fill in the biodata, education, experience, talents, and photo.Ģ. use: Anyone who knows how to use produce a curriculum vitae in PDF for free. This will ensure that your resume / CV focuses on the expectations of international hiring managers.įree curriculum vitae builder software with 2021 curriculum vitae instructions.ġ. Create a Fresh and unique content resume cover curriculum vitae.īased on data and the latest trends in many industries in India and the United States, Savvy CV created a resume builder (CV maker) with professional resume templates (US). 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There are multiple design resume templates available for freshnes and experienced professionals, with each resume and CV template available in resume designs Available. In just a few minutes, you can produce a professional resume or curriculum vitae (CV) for job applications using this free resume generator app. In just a few minutes, you can produce a professional resume or curriculum vitae (CV Maker) for job applications using this resume generator app To create resume you do not need to worry about what format Resume Maker provides you readymade resume formats resume Builder. In the era of cultural globalization Poland has ceased toīe perceived as a distant and exotic country, and the works of Polish In recentĭecades, however, there have been some positive changes, above all theĪppearance of competent and talented translators translating directlyįrom Polish. Such as Henryk Sienkiewicz once and Wisława Szymborska recentlyĭo not entail arousing interest in Polish literature as such. Published and still appear in small publishing houses, which means that Of the translations from Polish were done by few and not necessarily Of publishers to market authors representing an almost unknown culture, Review shows that the main obstacle was and still is the lack of willingness Of translating literary works from the so-called “minor cultures” on theĮxample of the reception of Polish literature in Italy. more The essay proposes a brief reflection on the mechanisms Of translating literary works from the so. The essay proposes a brief reflection on the mechanisms The decades, the most ambitious attempt at adaptation, Quo vadisįor 10–year-olds, published in the 1930s in the famous La Scalaĭ’oro publishing series, is discussed in detail. Of the dozens ofĭifferent versions for young readers that were created in Italy over In which readers got acquainted with the text. Of the novels aimed at students of junior high school, aged 11–14,ĭominated the publishing market and became the primary form Finally, the post ww2 context, when adaptations The interwar period, when the adaptations of Quo vadis became books intended for reading as school The work appeared, censored from content considered too bold TheĮarliest one, up to the First World War, when “purified” versions of Three historical phases of the work's reception are analyzed. Vadis and their key role in long term success of the novel in Italy. more The article discusses the adaptations of Henryk Sienkiewicz's Quo The article discusses the adaptations of Henryk Sienkiewicz's Quo Obviously, the first step in setting Private Internet Access up is signing up for the service. Step 1: Sign Up for Private Internet Access Learn how to sign up for, download, and install Private Internet Access below. 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I wanted to go with this design in part as an homage to my first woodworking employer, Roy Griffiths, from whom I learned a lot about proportions and design, as well as the realities of making a living as a full-time woodworker. The stained cypress plate rack in our former kitchen. Then someone asked about the more elaborate design of the example I made for the kitchen at our previous home. When the editors and I were trying to nail down a design for this project article (which is not yet scheduled for a particular issue), we initially thought we’d go with a simple design I made up a few years ago for my book Kitchen Think. A number of people have commented on the design following Instagram posts, so I’d like to share the backstory, which goes back to my first professional job as a woodworker in 1980. It’s a simple piece with lots of hand-cut joinery and will hold a variety of stuff. Last week, Senior Editor Anissa Kapsales and I completed a long-delayed photo shoot for an article about how to build the plate rack pictured at the top of this post. It may be pegged - I hope it’s pegged, because without some type of reinforcement it would not make for a secure way to support heavy, breakable dishware! (A detail shot, below, shows this feature more clearly.) Please don’t ask about the tenon at front bottom that comes through the stiles. Nor did it originally have the circular section at the top, which allows for storage and drainage of glassware and mugs. The original plate rack did not have notches above the plates on the lower level those were added to make room for Claudia’s plates. Historically, they were simple affairs, pared down to basics, such as this Irish example: Woodworker, author, and historian of Irish vernacular furniture Claudia Kinmonth inherited this simple plate rack from her grandmother. But they can also be decorative objects in their own right. Plate racks are handy for draining dishes and storing everyday dishware. The world of plate racks is rich in varied examples - and nowhere more so than among the works of English kitchen designer Johnny Grey. Simply cut the stem ensuring that there is at least one root node in each cutting, either root the cutting in water or plant it directly in soil ensuring that the root node is inside the growing medium. Propogation : Money plant is one of the easiest plants to be propagated and it can be done through stem cuttings. Repotting : Once your Money Plant is growing well and thriving, repot it in a slightly larger pot when it becomes root bound and the growth slows down. Also use a well rotten cow dung manure at the time of potting and repotting the plant. Pun intendedįertilizer/ feed for the plant:Feed your money plant with organic fertilisers once a month in winters and every two weeks from spring to summer. 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Hanging planters are also a great option to display their beauty to its full impact. You can also grow it in empty glass bottles and place it in compact spaces like bathroom windowsill or kitchen counters to make the space greener. Let it climb on walls, trail from shelves, or simply cover your window grills to lend your room a tropical feels. Styling/decor tip : The money plant instantly livens up any space by adding a splash of beautiful green colour. You can keep your money plant indoors in your living room or kitchen or even on your study table! Locations : Money Plants grow best in warm spots with indirect sunlight so pick a location accordingly. Low to medium light sometimes leads to beautiful variegations on the leaves. Indoors, money plant can also grow in full shade. Direct harsh sunlight can harm your Money Plant. Bright light boosts the growth of this no-fuss houseplant. You can also click related recommendations to view more background images in our huge database.Light Requirements : The Money Plant requires bright and indirect or dappled natural sunlight. 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BELIEVABLE WORLD: Ultra realistic graphics showcase lush landscapes for you to explore, battle over and claim as your own.COMMUNITY & MULTIPLAYER: Compete with players all over the world or locally in LAN matches, mod* the game in unprecedented ways, and install mods directly from an in-game community hub without ever leaving the game.ALL NEW FEATURES: A new hex-based gameplay grid opens up exciting new combat and build strategies.WIDE SYSTEM COMPATIBILITY: Civilization V operates on many different systems, from high end desktops to many laptops. City States become a new resource in your diplomatic battleground. An improved diplomacy system allows you to negotiate with fully interactive leaders. *Modding SDK available as a free download. Note: The Mac and Linux + SteamOS versions of Sid Meier's Civilization V are available in English, French, Italian, German and Spanish only.*Update : We are aware of an issue surrounding the 2K Launcher and players not being able to access their Civilization game/DLC content. Please keep an eye on the Civilization Twitter account for the most up-to-date information on a fix.* We've recently created a new launcher for Civilization V and Civilization VI. We know you might want to know some more info about them, so we've put together a list of likely questions (along with their answers) below. Think of the launcher as a hub for all things Civilization.From it, you can launch the game, select the version of DirectX to use, and get the latest info from the newsfeed. What languages does the launcher support? The newsfeed contains content from the Civilization blog and YouTube channel. The launcher is a fixed size that can't be adjusted. What are the launcher's system requirements? If your system can launch Steam, it'll support the launcher.You may encounter issues with the launcher on Windows XP and Vista.If your computer is running Windows XP or Vista, please be aware that Steam will stop supporting those OSs on January 1, 2019. The launcher closed and the game isn’t running, but Steam says the game is still running. This may happen if the launcher is not able to properly shutdown.You may need to manually end a couple of Windows processes. Find the processes called "QtWebEnginerProcess.exe." 35 Best Civilization 6 Mods On Steam (All Free) BY Paolo Owyong This post may contain affiliate links.If you buy something we may get a small commission at no extra cost to you. There are loads of updates in Civ6 well worth exploring. Select each of these processes and click the End Process button.Like the introduction of city districts, the separation of the tech and civics trees, and. I'm running Windows XP/Vista and am having trouble getting the launcher to work. Sid Meiers Civilization V: Complete Edition (PC) for Steam platform is a digital download product no box included.If you're on one of those operating systems, try this workaround: Please remember that as of January 1, 2019, Steam will no longer support Windows XP or Vista. In the text box to "Enter beta access for to unlock private beta:" enter the password "ineedlegacyaccess".Right click on the game in your library and choose "Properties.".Open up Steam and navigate to your LIBRARY. You should see a confirmation message that access has been granted.If not already selected in the drop down, select "legacy" and click close.Steam may require you to download and update for the game.Wait for this to happen or force it using "LIBRARY -> DOWNLOADS". |
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